The liver is the hardest working organ in the human body. Poor diet, chemicals, pathogenic organisms, antibiotics, hormone replacement, and a lack of essential nutrients impair the liver’s ability to filter and detoxify harmful substances. Almost 2 quarts of blood pass through the liver every minute for detoxification. Filtration of toxins is absolutely critical as portal venous blood from the intestines contains high levels of broad spectrum of microorganisms such as bacteria, fungi, viruses, parasites and other by-products and toxins.
The liver also neutralises a wide range of exo/endo toxic chemicals, . Allergies, sluggish metabolism and hormonal imbalances among others, are also a result of compromised digestive and hepatic function.
Detoxification occurs in two sequential steps – Phase I and Phase II. This complex system works together to convert (biotransform) toxic fat soluble molecules into non -toxic, water soluble molecules for rapid excretion. Complex nutrients and botanical co-factors specific to each phase are necessary to ensure accurate conversion.
Liver detoxification proceeds via two enzyme pathways: 1) Phase I P450 enzymes convert toxins into water soluble intermediates; 2) Phase II conjugation enzymes transform these intermediates into compounds which can be excreted via the kidneys or bile. Phase I intermediate metabolites can be 60 times more toxic than their fat-soluble precursors. These water soluble intermediates combine with oxygen, creating free radicals that cause extensive damage to the liver and other cells of the body.
As is apparent, a balance of Phase I and Phase II enzymes is crucial for efficient and safe detoxification processes. Inadequate Phase II liver detoxification is common in cases of long term xenobiotic exposure, where nutritional factors required for conjugation are depleted. The slow release of these toxins into the bloodstream is a major factor in the development of chronic disease.
Essential vitamins, minerals, and amino acids provide nourishment to the body in this phase and are supportive in the repair of damaged tissues. Specific amino acids support Phase II conjugation enzymes, while plant polyphenols provide intense antioxidant support to neutralize damage caused by Phase I created, intermediate metabolites. Liver/gall bladder protective and restorative botanicals are included in this formula to assist with ongoing decongestion and repair.