Why is there so much Vitamin D Deficiency
For those who prefer to listen and watch I have included a video of Dr Cass, the master Formulator of the product that
I use personally and offer to my patients, he explains the importance of Vitamin D and the reasons behind this powerful formulation.
First of all I want to just point out that there are many vitamin D products on the market – some are synthetically produced which means the absorption factor will be extremely low so basically a waste of money – some are supplied in a tablet form which again has very low absorption and then there is the powder form in a capsule – You may have seen these forms labelled as Vitamin D – Vitamin D 1( not used now but was a combination) or vitamin D2
Having said that let us follow the process of how our body creates and uses vitamin D. Don’t worry too much about the technical names the main point is to understand how our body converts cholesterol through various chemical and systemic processes – and the importance of cholesterol in the body.
Fat-soluble Vitamin D3 is converted by the kidneys into the hormone calcitriol, the activated form of Vitamin D3 which affects a variety of target tissues including bone, intestine, muscle, brain, skin and immune system cells.
Calcitriol enhances calcium and phosphorous absorption and stimulates the synthesis of osteocalcin, an important structural protein in bone.
Calcitriol is also involved in proper cell differentiation (changing of cell function), including prostate, breast and colon cells.
Here we explore the different Forms of Vitamin D
To understand vitamin D pharmacology, one needs to be familiar with the different forms of vitamin D, namely cholecalciferol, calcidiol, and calcitriol.
Cholecalciferol (vitamin D3)
Cholecalciferol is the naturally occurring form of vitamin D. It is the substance made in large quantities in the skin when sunlight strikes bare skin. It can also be taken as a supplement. Cholecalciferol is vitamin D; all other compounds are either metabolic products or chemical modifications, (eg. ergocalciferol D2)
Calcidiol (25(OH)D3 or 25D3) Calcidiol (25-hydroxyvitamin D) is a pre-hormone in the blood that is directly made from cholecalciferol. When being tested for vitamin D deficiency, calcidiol is the only blood test that should be drawn. When someone refers to vitamin D blood levels, they are usually referring to calcidiol levels.
Calcitriol (1,25(OH)2D3 or 1,25D3)
Calcitriol (1,25-dihydroxyvitamin D) is made from calcidiol in the kidneys and in tissues and is the most potent steroid hormone derived from cholecalciferol. In fact, it is the most potent steroid hormone in the human body. Calcitriol may have significant anti-cancer activity. It is sometimes referred to as the active form of
vitamin D. Calcitriol levels should never be used to determine vitamin D deficiency.
After the liver turns cholecalciferol into calcidiol, calcidiol follows one of two pathways.
The first priority for calcidiol is to go to the kidney where it makes enough calcitriol to regulate serum and cellular calcium. However, if the reserve is low, or if the liver phases of detoxification are compromised due to faulty conversion processes, most calcidiol takes the first pathway as survival always comes first in the physical hierarchy.
Calcitriol is a potent steroid hormone; in fact, it is the most potent steroid hormone in the human body.
So, the first pathway takes priority—as our lives literally depend on it—but it is the second pathway that’s causing all the excitement.
The second vitamin D pathway leads to the tissues and that is where all the action is. All of the amazing health benefits of vitamin D discovered in the last 10 years are from vitamin D going down the second pathway.
If any calcidiol is left over— that is if the reserve is full and the kidneys are getting all the calcidiol they need to maintain serum calcium—then calcidiol is able to take another pathway, one that leads directly to the cells.
This path is only now being fully understood and is causing excitement all around the world, especially concerning serious conditions. These are the autocrine (inside the cell) and paracrine (around the cell) functions of the vitamin D system.
These functions are crucial to understanding why we should keep vitamin D reserves full.
If there is only a small amount of calcidiol in the blood, virtually all of it goes to the kidney, which then makes extra calcitriol to keep serum calcium levels from falling, however almost no calcidiol gets to your tissues to make tissue calcitriol.
When the reserve is full, however, the leftover calcidiol goes to the
many cells in the body that are able to make their own calcitriol to fight various conditions (degenerative and otherwise) – and they do so with gusto! In fact, they appear to make as much calcitriol as they can. The more calcidiol they get, the more calcitriol they make. The step is not rate-limited by its product (calcitriol) and is thus uncontrolled.
No other steroid hormone system in the body works this way; the manufacture of calcitriol in the tissues is unique. In other words, there is no negative feedback loop mechanism in place relative to calcidiol and calcitriol.
This is one of the most important facts about vitamin D.
Calcitriol is arguably the most potent steroid hormone in the human body.
It turns genes on and off at a dizzying rate. These are genes that are either making proteins that are essential to fighting cancer, or genes that are making proteins that are promoting diseases like cancer.
However, without the presence of the correct ratio of Vitamin K2 in the form of MK-7, the mechanism is thwarted. This is equally true with respect to D3. As you have discovered, these two wonderful, natural vitamins are so much more effective together than alone.
The Calcium Paradox: Vitamin D3 is required for the absorption of minerals such as calcium, whereas vitamin K2 is needed to direct the minerals to the right place, preventing an inappropriate calcification of soft tissues. Likewise, cells only produce osteocalcin and the matrix Gla-protein (MGP) in the presence of vitamin D, but vitamin K2 (MK-7) is necessary to activate those proteins to fulfil their purpose.
Why are so many people plagued by a lack of calcium in the bones (osteoporosis) along with an excess of calcium in the arteries (atherosclerosis)? Researchers have finally uncovered the connection between these two serious health conditions: Vitamin K2 (MK-7) and Vitamin D3!
Vitamin D3 and Vitamin K2 (MK-7) deficiency is a worldwide epidemic. Over 1 billion people are at risk for its associated conditions beyond just this winter’s viral concerns. Almost daily, references to vitamin D dominates the headlines. Paradoxically, very little is being said about Vitamin K2.
However, there is overwhelming evidence confirming that the safety of vitamin D is dependent on adequate vitamin K2 (MK-7). Vitamin K is the name of a group of compounds that are all related to one another. The first one discovered was Phylloquinone or K1. K1 is the form in which vitamin K produces clotting factors. Produced by plants and algae, K1 is found in green leafy vegetables such as broccoli, kale and Swiss chard, and in plant oils, such as canola and soybean oil.
In the last decade, most of the research has turned to more effective Menaquinones or vitamin K2. Supplemental vitamin K2 exists in several forms. The most common ones are the synthetic menaquinone-4 (MK-4) and the natural menaquinone-7 (MK-7).
Recent studies have shown the more expensive vitamin MK-7 to be more complete and have additional heart condition benefits including the inhibition of calcium deposits in the arteries. MK-4 has to be applied in very high pharmacological doses (milligrams) to demonstrate benefits for bone and heart health. In case of MK-7, doses in micrograms – 1000x less – are sufficient for significant bioactive effect.
The longer half-life of MK-7 results in significantly better accumulation compared to MK-4. Research shows that in only 8 days MK-7 has 6 times better absorption. All K vitamins are similar in structure but differ in the length of the “side chain”. The longer the side chain, the better effect and efficiency. Consequently, the long-chain menaquinones (especially MK-7) are the most desirable as they are nearly completely absorbed (body requires smaller doses) and stay in the blood for the longest time. Meaning, vitamin K2 is also available for tissues outside the liver, namely bones, arteries and soft tissues (Fig 1).
K2 has been reported to decrease serum cholesterol and cholesterol deposits in the aorta, contributing to the suppression of atherosclerosis.
Some Study Results
Vitamin K2 (MK-7) has been linked to a reduction in coronary heart disease. In fact, one very large and significant study conducted in the Netherlands in 2004 followed 4800 healthy men and women for ten years. It was found vitamin K2 reduced the risk of coronary heart disease mortality by 50% aortic calcification was also reduced by 30-40% in the famous Rotterdam study.
A 3-year study of 325 postmenopausal women receiving either K2 or placebo found that supplementation with K2 can prevent bone loss associated with estrogen decline. In the women given K2, bone mineral content increased, and hip and bone strength remained unchanged, whereas, in the placebo group, bone mineral content and bone strength decreased significantly.
A number of trials have shown that the combination of K2 and vitamin D3 is more effective in preventing bone loss than either nutrient alone.
Canadian Cancer Society recommends that “Adults at higher risks of having lower levels of Vitamin D should consider taking a Vitamin D supplement of 1000 IU/day all year round.” The form of Vitamin D3 (cholecalciferol) is derived from the lanolin in sheep’s wool and should be free of Vitamin A.
Advanced Nanosphere Technology TM
Vitamin D3 with vital complement Vitamin K2 (MK-7)